Expression and Sequence of CYP1A1 in Camel

Abstract

In this study, we determined the CYP1A1 partial sequence in camel and its phylogenetic position. The deduced amino acid sequence of camel CYP1A1 showed the highest identity with that of sheep and cattle CYP1A1 at 94%. In the phylogenetic analysis, the camel CYP1A1 isoform was located beside sheep and cattle CYP1A1. When we studied the distribution of camel CYP1A1 mRNA in different tissues, we found that this isoform was expressed in all tissues except the hump. Interestingly, lung of all camels and tongue from two of three animals showed high expression of CYP1A1 mRNA, and this may indicate exposure to ligands of aryl hydrocarbon receptor such as environmental pollutants or flavonoids.