Evaluation of Myanmar Medicinal Plant Extracts for Antitrypanosomal and Cytotoxic Activities

Saw BAWM; Saruda TIWANANTHAGORN; Kyaw San LIN; Junichi HIROTA; Takao IRIE; Lat Lat HTUN; Ni Ni MAW; Tin Tin MYAING; Nyunt PHAY; Satoshi MIYAZAKI; Tatsuya SAKURAI; Yuzaburo OKU; Hideyuki MATSUURA; Ken KATAKURA

doi:10.1292/jvms.09-0508

This article has now been updated. Please use the final version.

Evaluation of Myanmar Medicinal Plant Extracts for Antitrypanosomal and Cytotoxic Activities

Saw BAWM, Saruda TIWANANTHAGORN, Kyaw San LIN, Junichi HIROTA, Takao IRIE, Lat Lat HTUN, Ni Ni MAW, Tin Tin MYAING, Nyunt PHAY, Satoshi MIYAZAKI, Tatsuya SAKURAI, Yuzaburo OKU, Hideyuki MATSUURA, Ken KATAKURA

Author information

Saw BAWM
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
Saruda TIWANANTHAGORN
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
Kyaw San LIN
Department of Pharmacology and Parasitology, University of Veterinary Science
Junichi HIROTA
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
Takao IRIE
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
Lat Lat HTUN
Department of Pharmacology and Parasitology, University of Veterinary Science
Ni Ni MAW
Livestock Breeding and Veterinary Department
Tin Tin MYAING
Department of Pharmacology and Parasitology, University of Veterinary Science
Nyunt PHAY
Pathein University
Satoshi MIYAZAKI
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
Tatsuya SAKURAI
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
Yuzaburo OKU
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
Hideyuki MATSUURA
Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
Ken KATAKURA
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University

Keywords: antitrypanosomal activity, Myanmar medicinal plants, Trypanosoma evansi, Vitis repens

JOURNAL FREE ACCESS Advance online publication

Article ID: 09-0508

DOI https://doi.org/10.1292/jvms.09-0508

The final version of this article is now available: Vol. 72 (2010) , No. 4 p.525

Details

Abstract

Current chemotherapeutic options for African trypanosomiasis in humans and livestock are very limited. In the present study, a total of 71 medicinal plant specimens from 60 plant species collected in Myanmar were screened for antitrypanosomal activity against trypomastigotes of Trypanosoma evansi and cytotoxicity against MRC-5 cells in vitro. The methanol extract of dried rootbark of Vitis repens showed the highest antitrypanosomal activity with IC₅₀ value of 8.6 ± 1.5 μg/ml and the highest selectivity index of 24.4. The extracts of Brucea javanica, Vitex arborea, Eucalyptus globulus and Jatropha podagrica had also remarkable activity with IC₅₀ values and selectivity indices in the range of 27.2–52.6 μg/ml and 11.4–15.1, respectively.

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