Anti-Inflammatory Potency of Oral Disulfiram Compared with Dexamethasone on Endotoxin-Induced Uveitis in Rats

Kazutaka KANAI; Naoyuki ITOH; Yoshimasa ITO; Noriaki NAGAI; Yasutomo HORI; Seishirou CHIKAZAWA; Fumio HOSHI; Seiichi HIGUCHI

doi:10.1292/jvms.10-0239

This article has now been updated. Please use the final version.

Anti-Inflammatory Potency of Oral Disulfiram Compared with Dexamethasone on Endotoxin-Induced Uveitis in Rats

Kazutaka KANAI, Naoyuki ITOH, Yoshimasa ITO, Noriaki NAGAI, Yasutomo HORI, Seishirou CHIKAZAWA, Fumio HOSHI, Seiichi HIGUCHI

Author information

Kazutaka KANAI
Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University
Naoyuki ITOH
Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University
Yoshimasa ITO
Department of Advanced Design for Pharmaceuticals, School of Pharmacy, Kinki University
Noriaki NAGAI
Department of Advanced Design for Pharmaceuticals, School of Pharmacy, Kinki University
Yasutomo HORI
Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University
Seishirou CHIKAZAWA
Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University
Fumio HOSHI
Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University
Seiichi HIGUCHI
Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University

Keywords: anti-inflammatory potency, dexamethasone, diethyldithiocarbamate, disulfiram, endotoxin-induced uveitis

JOURNAL FREE ACCESS Advance online publication

Article ID: 10-0239

DOI https://doi.org/10.1292/jvms.10-0239

The final version of this article is now available: Vol. 73 (2011) , No. 4 p.517

Details

Abstract

To investigate potency of oral disulfiram (DSF) compared with that of dexamethasone (Dexa), on endotoxin-induced uveitis (EIU) in rats. The oral administration with 750 mg/kg DSF suppressed the number of inflammatory cells, protein concentration, and levels of tumor necrosis factor (TNF)-α, Nitric oxide (NO) and prostaglandin (PG) E2 in the aqueous humor and improved the histiologic status of the ocular tissue at 24 hr after lipopolysaccharide (LPS) injection. The anti-inflammatory potency of DSF oral administration was as strong as that observed with 0.5 mg/kg Dexa in the present study. The results suggest that DSF might pave the way for a novel therapeutic agent for the management of uveitis.

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