Usage of Analgesic in Murine Model Infected Latently with Pseudorabies Virus

Abstract

Butorphanol tartrate (BT) was injected into mice before the acetylcholine injection in a murine model infected latently with pseudorabies virus. The analgesic effect and its influence on virus reactivation were observed. Mice pre-injected with BT showed suppression of screaming, moving and excitation, and the same level of movement after excitation as mice injected with PBS. In the group with BT injection i.p., one mouse died and another developed diarrhea and virus excretion increased. These results showed that BT has analgesic effects by both injection routes, s.c. and i.p.; however, BT induced death as a side effect, especially with i.p. injection. The injection route of BT should therefore be investigated further.