Expressions of Protein Oxidation Markers, Dityrosine and Advanced Oxidation Protein Products in Cisplatin-Induced Nephrotoxicity in Rats

Yumi KIMOTO; Akihiko SUGIYAMA; Masaaki NISHINOHARA; Atsushi ASANO; Aino MASUDA; Tairin OCHI; Takashi TAKEUCHI

doi:10.1292/jvms.10-0371

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Expressions of Protein Oxidation Markers, Dityrosine and Advanced Oxidation Protein Products in Cisplatin-Induced Nephrotoxicity in Rats

Yumi KIMOTO, Akihiko SUGIYAMA, Masaaki NISHINOHARA, Atsushi ASANO, Aino MASUDA, Tairin OCHI, Takashi TAKEUCHI

著者情報

キーワード: advanced oxidation protein product, cisplatin, dityrosine, nephrotoxicity, oxidative stress

ジャーナルフリー早期公開

論文ID: 10-0371

DOI https://doi.org/10.1292/jvms.10-0371

この記事には本公開記事があります。

The final version of this article is now available: Vol. 73 (2011) , No. 3 p.403

詳細

抄録

The purpose of this study was to evaluate whether dityrosine and advanced oxidation protein products (AOPP) reflect the severity of cisplatin-induced nephrotoxicity. Immunoexpression of dityrosine in kidneys and plasma AOPP concentration were examined up to day 4 post-cisplatin injection in rats. Cisplatin injection induced tubular injury on days 2–4 after injection and increased serum creatinine and BUN on days 3 and 4. On days 2–4, dityrosine was immunostained in the cytoplasm of damaged tubular cells, and their immunostaining intensity increased time-dependently. Plasma AOPP levels were significantly increased on days 3 and 4. These results suggest that expressions of dityrosine and AOPP were associated with the severity of renal injury and may be useful markers for the development of cisplatin-induced nephrotoxicity.

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