The Effect of Aloe Vera Oral Administration on Cutaneous Wound Healing in Type 2 Diabetic Rats

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Delayed wound healing is one of the complications of diabetes mellitus. The present study was planned to investigate the effect of Aloe vera oral administration on open wounds in type 2 diabetic rats. Full thickness open wounds (1.5 × 1.5 cm) were created under general anesthesia on the back of the rats. These rats were divided into two groups; control group (Group C) and Aloe vera oral administration group (Group A). Each wound area was measured on days 1, 2, 4 and 8 post-wounding. The stages of wound granulation tissues were evaluated histopathologically. The expression of transforming growth factor (TGF)-β1 and vascular endothelial growth factor (VEGF) were determined by immunohistochemically. The wounds were contracted significantly in Group A on days 2, 4 and 8 post-wounding. Histological results revealed that the inflammatory cell infiltration, angiogenesis, extracellular matrix deposition and epithelialization were promoted in Group A, respectively. The immunohistochemical results revealed that both TGF-β1 and VEGF protein positive cells increased in Group A on day 4 post-wounding. We concluded that Aloe vera oral administration accelerated wound healing in type 2 diabetic rats.