Full Genome Sequence and Virulence Analyses of the Recent Equine Isolate of Japanese Encephalitis Virus

Masayuki SHIMOJIMA; Yumiko NAGAO; Hiroshi SHIMODA; Seiji TAMARU; Takashi YAMANAKA; Tomio MATSUMURA; Takashi KONDO; Ken MAEDA

doi:10.1292/jvms.10-0502

This article has now been updated. Please use the final version.

Full Genome Sequence and Virulence Analyses of the Recent Equine Isolate of Japanese Encephalitis Virus

Masayuki SHIMOJIMA, Yumiko NAGAO, Hiroshi SHIMODA, Seiji TAMARU, Takashi YAMANAKA, Tomio MATSUMURA, Takashi KONDO, Ken MAEDA

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Keywords: genotype, horse, Japanese encephalitis virus, sequence, virulence

JOURNAL FREE ACCESS Advance online publication

Article ID: 10-0502

DOI https://doi.org/10.1292/jvms.10-0502

The final version of this article is now available: Vol. 73 (2011) , No. 6 p.813

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Abstract

In the past 25 years, there has been only one case of Japanese encephalitis in horses in Japan. We determined the full genome sequence of the Japanese encephalitis virus (JEV) strain JEV/eq/Tottori/2003 isolated from an afflicted horse and also analyzed its virulence in mice. The sequence analysis showed that the genome of JEV/eq/Tottori/2003 is similar to that of genotype I, a dominant genotype of JEV presently circulating in Japan. Its neurovirulence, but not neuroinvasiveness, was still as high as it was for genotype III, thus indicating the necessity for continuation of a vaccination program of horses against JEV.

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