Plasma Profiles of Glucose, Insulin and Lipids in the Male WBN/Kob-Leprfa Rat, a New Model of Type 2 Diabetes with Obesity

Noriyuki KAJI; Akira OKUNO; Kanako OHNO-ICHIKI; Hisako OKI; Haruya ISHIZAWA; Mitsuyuki SHIRAI; Fumitoshi ASAI

doi:10.1292/jvms.12-0045

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Plasma Profiles of Glucose, Insulin and Lipids in the Male WBN/Kob-Lepr^fa Rat, a New Model of Type 2 Diabetes with Obesity

Noriyuki KAJI, Akira OKUNO, Kanako OHNO-ICHIKI, Hisako OKI, Haruya ISHIZAWA, Mitsuyuki SHIRAI, Fumitoshi ASAI

著者情報

キーワード: glucose, insulin, lipid, type 2 diabetes, WBN/Kob-Lepr^fa rat

ジャーナルフリー早期公開

論文ID: 12-0045

DOI https://doi.org/10.1292/jvms.12-0045

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2012), No. 9 pp. 1185-1189

詳細

抄録

Plasma profiles of glucose, insulin and lipids were examined in the male WBN/Kob-Lepr^fa (fa/fa) rat, a new model of type 2 diabetes (T2D), in comparison with age-matched original male WBN/Kob (lean) rats. The fa/fa rats developed hypertriglycemia, obesity and hyperglycemia from 5, 7, and 9 weeks of age, respectively. Plasma insulin levels in fa/fa rats were significantly higher than those in lean rats at 5 weeks of age, but after 11 weeks of age gradually declined to the levels in lean rats. HOMA-IR, a measure of insulin resistance status, showed that fa/fa rats had insulin resistance. The fa/fa rat has the potential to become an important animal model of T2D with obesity.

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