Detection of Ascitic Feline Coronavirus RNA from Clinically Suspected Cats of Feline Infectious Peritonitis

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Ascitic feline coronavirus (FCoV) RNA was examined in 854 feline infectious peritonitis (FIP)-suspected cats by RT-PCR. The positivity was significantly higher in purebreds (62.2%) than in crossbreds (34.8%) (P<0.0001). Among purebreds, the positivity in Norwegian Forest Cat (92.3%) and Scottish Fold (77.6%) were significantly higher than the average of purebreds (P=0.0274 and 0.0251, respectively). The positivity was significantly higher in males (51.5%) than in females (35.7%) (P<0.0001), whereas no gender difference has generally been noted in FCoV antibody-prevalence, indicating that FIP more frequently develops in males among FCoV-infected cats. Genotyping was performed for 377 gene-positive specimens. Type I (8.3%) was far more predominantly detected than type II (10.6%) (P<0.0001), similar to previous serological and genetic surveys.