N-Acetyl-D-Mannosamine Treatment Alleviates Age-Related Decline in Place-Learning Ability in Dogs

Miho NAGASAWA; Aki SHIMOZAWA; Kazutaka MOGI; Takefumi KIKUSUI

doi:10.1292/jvms.13-0351

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N-Acetyl-D-Mannosamine Treatment Alleviates Age-Related Decline in Place-Learning Ability in Dogs

Miho NAGASAWA, Aki SHIMOZAWA, Kazutaka MOGI, Takefumi KIKUSUI

著者情報

キーワード: active-resting cycle, age-related cognitive dysfunction, cognitive ability, N-acetyl-D-mannosamine

ジャーナルフリー早期公開

論文ID: 13-0351

DOI https://doi.org/10.1292/jvms.13-0351

この記事には本公開記事があります。

The final version of this article is now available: Vol. 76 (2014), No. 5 pp. 757-761

詳細

抄録

This study aimed to investigate the therapeutic effects of N-acetyl-d-mannosamine (ManNAc) on age-related cognitive dysfunction in dogs. ManNAc was administered to 5 dogs with low cognitive levels for 2 months, and the cognitive ability and active-resting cycle were periodically assessed for improvement. ManNAc treatment significantly reduced the number of error trials in the place-learning test, especially in the first month of administration. Three ManNAc-treated dogs also showed improvement in the active-resting cycle. In conclusion, ManNAc treatment appears to alleviate age-related cognitive dysfunction.

責任著者(Corresponding author)

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