Diurnal Variation of Plasma Bone Markers in Japanese Black Calves

Asako MATSUO; Akira TOGASHI; Kouya SASAKI; Bhuminand DEVKOTA; Toh-ichi HIRATA; Norio YAMAGISHI

doi:10.1292/jvms.14-0021

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Diurnal Variation of Plasma Bone Markers in Japanese Black Calves

Asako MATSUO, Akira TOGASHI, Kouya SASAKI, Bhuminand DEVKOTA, Toh-ichi HIRATA, Norio YAMAGISHI

著者情報

キーワード: cattle, blood sample, bone markers, diurnal variation

ジャーナルフリー早期公開

論文ID: 14-0021

DOI https://doi.org/10.1292/jvms.14-0021

この記事には本公開記事があります。

The final version of this article is now available: Vol. 76 (2014), No. 7 pp. 1029-1032

詳細

抄録

To evaluate diurnal variation of plasma bone markers, blood samples were collected from five calves at 2-hr intervals throughout a 24-hr period. Tartrate-resistant acid phosphatase isoform 5b (TRAP5b), carboxy-terminal collagen crosslinks of type-I collagen (CTX), hydroxyproline, bone specific alkaline phosphatase (BALP) and osteocalcin were measured. Cosinor analysis showed a significant rhythm in all bone markers. The acrophase of each bone marker appeared from the early to late morning. The percentage ratio of the amplitude to mesor and the within-subject variability for CTx and osteocalcin were significantly larger than those for TRAP5b and BALP. This marked diurnal variation in five bone markers suggested that the time of blood sampling should be fixed when studying bone marker concentrations in bovine plasma.

責任著者(Corresponding author)

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