Expression of NG2 proteoglycan in the degenerated intervertebral disc in dachshunds

Mohammed ABDEL-HAKIEM; Ayuko YAMASHITA; Ayman ATIBA; Yasuhiko OKAMURA; Masaaki KATAYAMA; Haroun YOUSSEF; Hiroshi ISOMURA; Yuji UZUKA

doi:10.1292/jvms.14-0233

This article has now been updated. Please use the final version.

Expression of NG2 proteoglycan in the degenerated intervertebral disc in dachshunds

Mohammed ABDEL-HAKIEM, Ayuko YAMASHITA, Ayman ATIBA, Yasuhiko OKAMURA, Masaaki KATAYAMA, Haroun YOUSSEF, Hiroshi ISOMURA, Yuji UZUKA

Author information

Mohammed ABDEL-HAKIEM
Division of Veterinary Diagnostic Imaging, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
Department of Animal Surgery, Faculty of Veterinary Medicine, Assiut University
Ayuko YAMASHITA
Division of Veterinary Diagnostic Imaging, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
Ayman ATIBA
Division of Veterinary Diagnostic Imaging, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Kafrelsheikh University
Yasuhiko OKAMURA
Division of Veterinary Surgery, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
Masaaki KATAYAMA
Division of Veterinary Diagnostic Imaging, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
Haroun YOUSSEF
Department of Animal Surgery, Faculty of Veterinary Medicine, Assiut University
Hiroshi ISOMURA
Pathological Assist, Co.
Yuji UZUKA
Division of Veterinary Diagnostic Imaging, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University

Keywords: dachshunds, immunohistochemistry, intervertebral disc (IVD) degeneration, NG2 proteoglycan

JOURNAL FREE ACCESS Advance online publication

Article ID: 14-0233

DOI https://doi.org/10.1292/jvms.14-0233

The final version of this article is now available: Vol. 78 (2016), No. 1 pp. 97-100

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Abstract

The pathogenesis of intervertebral disc (IVD) degeneration is not fully understood. The biomolecular signaling pathways involved in the IVD degeneration require further investigation. The aim of this study was to investigate the expression of NG2 proteoglycan in the degenerated IVD. IVD samples were obtained from 16 Dachshunds that were confirmed to have IVD herniation and subsequently underwent hemilaminectomy. The samples were subjected to histological and immunohistochemical (IHC) examination. IHC revealed positive results for the expression of NG2 proteoglycan in all examined samples. The results showed the expression of NG2 proteoglycan by the degenerated IVDs.

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