Equine herpesvirus type 1 tegument protein VP22 is not essential for pathogenicity in a hamster model but is required for efficient viral growth in cultured cells

Ayaka OKADA; Satoko IZUME; Kenji OHYA; Hideto FUKUSHI

doi:10.1292/jvms.14-0648

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Equine herpesvirus type 1 tegument protein VP22 is not essential for pathogenicity in a hamster model but is required for efficient viral growth in cultured cells

Ayaka OKADA, Satoko IZUME, Kenji OHYA, Hideto FUKUSHI

著者情報

キーワード: equine herpesvirus, tegument protein, VP22

ジャーナルフリー早期公開

論文ID: 14-0648

DOI https://doi.org/10.1292/jvms.14-0648

この記事には本公開記事があります。

The final version of this article is now available: Vol. 77 (2015), No. 10 pp. 1293-1297

詳細

抄録

VP22 is a major tegument protein of equine herpesvirus type 1 (EHV-1) that is a conserved protein among alphaherpesviruses. However, the roles of VP22 differ among each virus, and the roles of EHV-1 VP22 are still unclear. Here, we constructed an EHV-1 VP22 deletion mutant and a revertant virus to clarify the role of VP22. We found that EHV-1 VP22 was required for efficient viral growth in cultured cells, but not for virulence in a hamster model.

責任著者(Corresponding author)

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