Protective efficacy of stockpiled vaccine against H5N8 highly pathogenic avian influenza virus isolated from a chicken in Kumamoto Prefecture, Japan in 2014

Koichiro GAMOH; Mari NAKAMIZO; Masatoshi OKAMATSU; Yoshihiro SAKODA; Hiroshi KIDA; Shoko SUZUKI

doi:10.1292/jvms.15-0324

This article has now been updated. Please use the final version.

Protective efficacy of stockpiled vaccine against H5N8 highly pathogenic avian influenza virus isolated from a chicken in Kumamoto Prefecture, Japan in 2014

Koichiro GAMOH, Mari NAKAMIZO, Masatoshi OKAMATSU, Yoshihiro SAKODA, Hiroshi KIDA, Shoko SUZUKI

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Keywords: disease control, efficacy, highly pathogenic avian influenza, low pathogenic avian influenza, vaccine

JOURNAL FREE ACCESS Advance online publication

Article ID: 15-0324

DOI https://doi.org/10.1292/jvms.15-0324

The final version of this article is now available: Vol. 78 (2016), No. 1 pp. 139-142

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Abstract

H5 highly pathogenic avian influenza (HPAI) viruses have spread worldwide, and antigenic variants of different clades have been selected. In this study, the national stockpiled vaccine prepared from A/duck/Hokkaido/Vac-1/2004 (H5N1) strain was evaluated for the protective efficacy against H5N8 HPAI virus isolated in Kumamoto prefecture, Japan, in April 2014. In the challenge test, all of the vaccinated chickens survived without showing any clinical signs and reduced virus shedding. It was concluded that the present stockpiled vaccine was effective against the H5N8 HPAI virus.

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