Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
Coexistence of two forms of disease-associated prion protein in extracerebral tissues of cattle infected with H-type bovine spongiform encephalopathy
Hiroyuki OKADAKohtaro MIYAZAWAKentaro MASUJINTakashi YOKOYAMA
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JOURNALS FREE ACCESS Advance online publication

Article ID: 16-0068

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Abstract

H-type bovine spongiform encephalopathy (H-BSE) is an atypical form of BSE in aged cattle. H-BSE is characterized by the presence of two proteinase K-resistant forms of disease-associated prion protein (PrPSc), identified as PrPSc #1 and PrPSc #2, in the brain. To investigate the coexistence of different PrPSc forms in the extracerebral tissues of cattle experimentally infected with H-BSE, immunohistochemical and molecular analyses were performed by using N-terminal-, core-region-, and C-terminal-specific anti-prion protein antibodies. Our results demonstrated that two distinct forms of PrPSc coexisted in the various extracerebral tissues.

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