Allyl isothiocyanate reduces liver fibrosis by regulating Kupffer cell activation in rats

Jeongtae KIM; Hyojin BANG; Meejung AHN; Yuna CHOI; Gi Ok KIM; Taekyun SHIN

doi:10.1292/jvms.17-0637

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Allyl isothiocyanate reduces liver fibrosis by regulating Kupffer cell activation in rats

Jeongtae KIM, Hyojin BANG, Meejung AHN, Yuna CHOI, Gi Ok KIM, Taekyun SHIN

著者情報

キーワード: allyl isothiocyanate, carbon tetrachloride, fibrosis, Kupffer cells

ジャーナルフリー早期公開

論文ID: 17-0637

DOI https://doi.org/10.1292/jvms.17-0637

この記事には本公開記事があります。

The final version of this article is now available: Vol. 80 (2018), No. 6 pp. 893-897

詳細

抄録

Allyl isothiocyanate (AITC), a metabolite of the glucosinolate sinigrin, protects the liver of rats injured by carbon tetrachloride (CCl₄). This study evaluated whether AITC reduces hepatic fibrosis in rats repetitively exposed to CCl₄. Serum chemistry showed that AITC (doses of 5 and 50 mg) administered to rats exposed to CCl₄significantly reduced the levels of alanine aminotransferase and aspartate aminotransferase activity that were elevated in CCl₄-intoxicated rats. The connective tissue in AITC-treated rats was significantly reduced based on Sirius staining. In addition, Kupffer cell activation was significantly reduced in the AITC and CCl₄ co-treated groups. Collectively, this study suggests that AITC mitigates hepatic fibrosis in rats repetitively exposed to CCl₄ with concurrent regulation of Kupffer cell and monocyte activation.

責任著者(Corresponding author)

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