Follicle sinus complexes (FSCs) in muzzle skin as postmortem diagnostic material of rabid dogs

Nozomi SHIWA; Chikage NAKAJIMA; Kazunori KIMITSUKI; Daria Llenaresas MANALO; Akira NOGUCHI; Satoshi INOUE; Chun-Ho PARK

doi:10.1292/jvms.18-0519

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Follicle sinus complexes (FSCs) in muzzle skin as postmortem diagnostic material of rabid dogs

Nozomi SHIWA, Chikage NAKAJIMA, Kazunori KIMITSUKI, Daria Llenaresas MANALO, Akira NOGUCHI, Satoshi INOUE, Chun-Ho PARK

著者情報

キーワード: follicle-sinus complex (FSC), Merkel cell, post-mortem diagnosis, rabid dog

ジャーナルフリー早期公開

論文ID: 18-0519

DOI https://doi.org/10.1292/jvms.18-0519

この記事には本公開記事があります。

The final version of this article is now available: Vol. 80 (2018), No. 12 pp. 1818-1821

詳細

抄録

Recently, we reported that follicle-sinus complexes (FSCs) in the muzzle skin are useful for postmortem diagnosis of rabid dogs. Here, we compared the sensitivity and specificity of detecting the viral antigen in the brain and FSCs of 226 suspected rabid dogs, and assessed whether the FSC harbored the virus genome and particles. The viral antigen was detected in 211 of 226 samples with 100% sensitivity and specificity. Viral RNA and particles were observed in the cytoplasm of Merkel cells (MCs). These results suggest that MCs are targets of virus infection and FSCs are useful material for diagnosing rabies.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）