Distribution of marbofloxacin within the bronchoalveolar region of healthy pigs

Moe IJIRI; Shingo ISHIKAWA; Yoshinori JIBIKI; Masataka MIYAZAWA; Akane SENOKUCHI; Seiji HOBO

doi:10.1292/jvms.20-0239

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Distribution of marbofloxacin within the bronchoalveolar region of healthy pigs

Moe IJIRI, Shingo ISHIKAWA, Yoshinori JIBIKI, Masataka MIYAZAWA, Akane SENOKUCHI, Seiji HOBO

著者情報

キーワード: bronchoalveolar lavage fluid, distribution, marbofloxacin, pig

ジャーナルオープンアクセス早期公開

論文ID: 20-0239

DOI https://doi.org/10.1292/jvms.20-0239

この記事には本公開記事があります。

The final version of this article is now available: Vol. 82 (2020), No. 8 pp. 1080-1083

詳細

抄録

The purpose of this study was to clarify the distribution of marbofloxacin (MBFX) within the bronchoalveolar region of pigs. Four clinically healthy pigs were intramuscularly injected with a single dose of MBFX (2mg/kg). Samples of plasma and bronchoalveolar lavage fluid (BALF) were obtained for each pig at 0 (before administration), 3, 8 and 24 hr after administration of MBFX. As a result, the MBFX concentrations in pulmonary epithelial lining fluid (ELF) and in alveolar cells showed a similar pattern of concentrations during the experimental period. The MBFX concentrations both in ELF and alveolar cells were higher than in plasma. These results suggest that intramuscularly injected MBFX was well distributed in the bronchoalveolar region.

責任著者(Corresponding author)

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