Generalized Lipofuscinosis in a Dog

Abstract

Generalized lipofuscinosis was found incidentally in a 3-year-old, male Japanese retriever dog. Lipofuscin and ceroid pigments were deposited extensively in various tissues and organs including the brain. The histological changes suggested vitamin E deficiency as a possible cause of the lipofuscinosis and differentiated it from neuronal ceroid-lipofuscinosis.