Abstract
Coccidioidomycosis was diagnosed in a 9-year-old Holstein-Friesian cow slaughtered at an abattoir in the Awaji-shima of Hyogo Prefecture. The subject had a large abscess in one of the mediastinal lymph nodes. The abscess was surrounded by a thick pyogenic membrane with granulation tissue and contained young to mature spherules with endospores of Coccidioides immitis.