Monoclonal Antibody S37 Induces Apoptosis in Bovine T Lymphoma Cells

Toshie SHINAGAWA; Naotaka ISHIGURO; Motohiro HORIUCHI; Morikazu SHINAGAWA

doi:10.1292/jvms.56.957

Journal of Veterinary Medical Science

Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250

Monoclonal Antibody S37 Induces Apoptosis in Bovine T Lymphoma Cells

Toshie SHINAGAWA, Naotaka ISHIGURO, Motohiro HORIUCHI, Morikazu SHINAGAWA

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Keywords: apoptosis, bovine T lymphoma, mAb

JOURNAL FREE ACCESS

1994 Volume 56 Issue 5 Pages 957-959

DOI https://doi.org/10.1292/jvms.56.957

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Abstract

Influences of 38 monoclonal antibodies (mAbs) on the growth of bovine T lymphoma cells (BTL-27) were examined. One of them, S37, inhibited the cell growth strikingly when it was added to the cultures. S37-treated cells showed DNA fragmentation containing∼200-base pair multiple patterns and chromatin condensation. This evidence suggested that mAb S37 induced apoptosis in BTL-27 cells.

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