Effect of Enzymes on the Growth of Human and Animal Rotaviruses

Abstract

The growth of group A human, bovine, equine and porcine rotaviruses were enhanced by pretreatment of virus with pancreatin, trypsin, protease, alkaline phosphatase or pepsin and incorporation of these enzymes in maintenance medium. In contrast, α-amylase or lipase inhibited the growth of equine and porcine rotaviruses. The other enzymes, adenosin deaminase, lactase, lysozyme, ribonuclease or triose-phosphate isomcrase gave little or no change in the growth of all four rotaviruses.