Effects of Oil Adjuvant on Systemic Response to Escherichia coli Lipopolysaccharide in Swine

Mari NORIMATSU; Yasuaki OGIKUBO; Akemi KOJIMA; Toshio TAKAHASHI; Gen WATANABE; Kazuyoshi TAYA; Shuji SASAMOTO; Yutaka TAMURA

doi:10.1292/jvms.57.1089

Mari NORIMATSU, Yasuaki OGIKUBO, Akemi KOJIMA, Toshio TAKAHASHI, Gen WATANABE, Kazuyoshi TAYA, Shuji SASAMOTO, Yutaka TAMURA

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Keywords: LPS, oil adjuvant, swine

JOURNAL FREE ACCESS

1995 Volume 57 Issue 6 Pages 1089-1091

DOI https://doi.org/10.1292/jvms.57.1089

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Abstract

Intramuscular injection of 0.1 mg/kg of Escherichia coli lipopolysaccharide (LPS) mixed with Freund's complete adjuvant (LPS+FCA) in piglets mititated the leukopenia and TNF-α and cortisol levels in the serum compared with that of LPS suspended in LPS-free saline. The endotoxin level in the serum of the LPS+FCA was remarkably reduced. These results suggest that the addition of oil adjuvant mitigate the systemic toxicity of LPS.

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