Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Time Course of Ethylene Thiourea in Maternal Plasma, Amniotic Fluid and Embryos in Rats Following Single Oral Dosing
Takayuki IWASEMasako YAMAMOTOMitsuyuki SHIRAIFumiaki AKAHORIToshio MASAOKATatsuya TAKIZAWAKazuyoshi ARISHIMAYasunobu EGUCHI
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1996 Volume 58 Issue 12 Pages 1235-1236

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Abstract

Ethylene thiourea (ETU) was administered once orally to pregnant rats on gestation day 12 at a dose of 200 mg/kg, and its concentration-time courses in the maternal plasma, amniotic fluid and embryos were investigated. The ETU concentrations in the maternal plasma and amniotic fluid reached the peak level about 2 hr after dosing, then declined gradually and had disappeared by 48 hr. In embryos, the concentration of ETU peaked at 30 min after dosing and disappeared at 48 hr. The prolonged exposure of the embryos to the high concentration of ETU in the amniotic fluid could be partially responsible for the teratogenic effect of ETU.

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© The Japanese Society of Veterinary Science
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