Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Characterization of the Feline Herpesvirus Type 1 Immediate Early Gene Expression
Yasushi KAWAGUCHIKen MAEDAMitsuru ONONaoaki YOKOYAMAKenjiro TSUBOTAKentaro FUJITAYukinobu TOHYAChieko KAITakeshi MIKAMI
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1996 Volume 58 Issue 8 Pages 715-721

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Abstract
We analyzed the mechanism for feline herpesvirus type 1 (FHV-1) immediate early (IE) gene expression. We demonstrated that (i) the transcription initiation site of the FHV-1 IE transcript lies in the putative FHV-1 ICP4 binding site, (ii) the FHV-1 IE transcript is spliced to remove 906 bp intron from the leader region, (iii) cis-acting elements of the FHV-1 IE promoter map both down- and up-stream of the transcription initiation site, and (iv) a deletion of a 58 bp sequence which includes the putative FHV-1 ICP4 binding site in the IE promoter resulted in significant induction of promoter activity by a FHV-1 IE gene product although the FHV-1 IE gene product slightly stimulates the FHV-1 IE promoter, indicating that the FHV-1 IE gene product down-regulates its own promoter via the region.
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© The Japanese Society of Veterinary Science
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