Persistence of High Virus Neutralizing Antibody Titers in Cats Experimentally Infected with Feline Immunodeficiency Virus

Yasuo INOSHIMA; Yasuhiro IKEDA; Mariko KOHMOTO; Marcelo Ricardo PECORARO; Masayuki SHIMOJIMA; Yukako SHIMOJIMA; Gouki INADA; Yasushi KAWAGUCHI; Keizo TOMONAGA; Takayuki MIYAZAWA; Takeshi MIKAMI

doi:10.1292/jvms.58.925

Yasuo INOSHIMA, Yasuhiro IKEDA, Mariko KOHMOTO, Marcelo Ricardo PECORARO, Masayuki SHIMOJIMA, Yukako SHIMOJIMA, Gouki INADA, Yasushi KAWAGUCHI, Keizo TOMONAGA, Takayuki MIYAZAWA, Takeshi MIKAMI

Author information

Yasuo INOSHIMA
Yasuhiro IKEDA
Mariko KOHMOTO
Marcelo Ricardo PECORARO
Masayuki SHIMOJIMA
Yukako SHIMOJIMA
Gouki INADA
Yasushi KAWAGUCHI
Keizo TOMONAGA
Takayuki MIYAZAWA
Takeshi MIKAMI
Author's Organization：
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo

Keywords: antibody, FIV, neutralization test

JOURNAL FREE ACCESS

1996 Volume 58 Issue 9 Pages 925-927

DOI https://doi.org/10.1292/jvms.58.925

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Abstract

The development of virus neutralizing (VN) antibody is one of the most effective host defense mechanisms against virus infection. In the present study, we developed a new VN assay against feline immunodeficiency virus (FIV) using a feline T-lymphoblastoid cell line, MYA-1 cells, based on inhibition of viral reverse transcriptase production. This assay is applicable to strains of FIV which can not infect CRFK cells. By using the assay, we examined long-term responses of VN antibody in cats experimentally infected with FIV. VN antibody titers increased progressively during first 30 weeks post inoculation and remained at high titers thereafter for 7 years of observation periods.

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