A Graph Genome Browser: Visualization of Structural Variations between Genomes using a Graph Structure

Abstract

Visualization for genomes contributes to evaluating and interpreting the difference between genomes. Graph genome is an emerging approach for representing diversities on genomes as a mathematical graph. For example, representing complex structural variations as a graph genome is more natural than representing such variations as differences from a reference genome. Here, we present a web-based graph genome browser, MoMI-G, that can visualize graph genomes with various kinds of annotations. We describe the utility of the graph genome browser by demonstrating an example of a fusion gene identified in a cancer cell line. The graph genome browser enables researchers to interactively analyze differences between genomes represented as graph genomes.