百日咳母兒免疫の研究

人胎盤に於ける凝集素の産生について

抄録

The mechanism of the transplacental immunization has not been fully clarified yet, though it's effectiveness is recognized by many workers. Two possibilities are conceivable: active immunization from the mother side and a passive one from the fetus side. The role of the human placenta in this immunization was investigated by the author applying the tissue culture method, and the agglutinin producing ability of the placentas from immunized and non-immunized pregnant mothers was compared. The results are as follows.
1) Placentas from immunized mothers produce agglutinin in the tissue culture. On the contrary, those from non-immunized do not.
2) Even the latter produces the agglutinin, when sensitized in a suspension of living H. pertussis or pertussis vaccine.
One may conclude that the agglutinin producing ability of the placenta of immunized pregnant mother plays an inportant role in the transplacental immunization against whooping cough.