The mechanism of the transplacental immunization has not been fully clarified yet, though it's effectiveness is recognized by many workers. Two possibilities are conceivable: active immunization from the mother side and a passive one from the fetus side. The role of the human placenta in this immunization was investigated by the author applying the tissue culture method, and the agglutinin producing ability of the placentas from immunized and non-immunized pregnant mothers was compared. The results are as follows.
1) Placentas from immunized mothers produce agglutinin in the tissue culture. On the contrary, those from non-immunized do not.
2) Even the latter produces the agglutinin, when sensitized in a suspension of living H. pertussis or pertussis vaccine.
One may conclude that the agglutinin producing ability of the placenta of immunized pregnant mother plays an inportant role in the transplacental immunization against whooping cough.

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There are already many reports about transitory apparition of numerous non-specific reactions in patient's serum in various liver diseases. The author has also reported the frequent occcurence of increased chicken hemagglutinin titer (H. A.) in infectious hepatitis. The sheep hemagglutinin titer also augments in hepatitis according to other reports. The following experiments were carried out in order to investigate the increase of these heterophile hemagglutinins in hepatitis.
1) Sheep, goat, rabbit and chicken hemagglutinin titers were determined with serum of 274 cases of healthy persons and various diseased patients and with serum of 225 cases of hepatitis patients including infectious ones.
The relation between each hemagglutinin was examined by absorption test with each red corpuscles.
These antibodies were differentiated from the Forssman antibody, by the absorbtion test with boiled guinea pig kidney.
These experiments were carried out according to the methods reported by Davidshon, Kumagaya and Hayashi. The results were as follows.
1) H. A. in serum of hepatitis patients were often higher than in that of healthy persons or patients of other dissases. P. B. tends to increase within the normal limits. However, no relationship was observed between H. A. and P. B. Rabbit hemagglutinin fiter had also the tendency to augment in hepatitis serum.
2) Sheep and goat red corpuscles have in their antigenicity much in common.
3) Three species of red corpuscles, chicken, rabbit and goat (sheep) have only little common antigenicity with one another
4) The chicken hemagglutinin increased in hepatitis serum was not identified as normal Forssmann antibody.

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Escherichia Coli in stools of healthy and diarrhetic infants were examined, in order to investigate the role of Escherichia coli infantile diarrhea.
1) Although the distribution of Escherichia coli O_1-25 varied much, it was O₁₅, O₂₁, O₁₁ etc, which were often implicated in diarrhea. Flowerer even healty infants showed a great variation.
2) O₂₆, O₅₅ and O₁₁₁, called pathogenic E. coli, were isolated in diarrhea, whereas they could be found only in a very low rate or not at all in healthy infants.
3) Klebsiella form and intermediate form were often detected in diarrhea.
4) In many cases of diarrhea lactose slow fermenting or nonfermenting bacilli predominated in the flora.

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