赤血球凝集反應に關する研究 (第3報)

肝炎患者血清に於ける各種異種血球凝集反應について

抄録

There are already many reports about transitory apparition of numerous non-specific reactions in patient's serum in various liver diseases. The author has also reported the frequent occcurence of increased chicken hemagglutinin titer (H. A.) in infectious hepatitis. The sheep hemagglutinin titer also augments in hepatitis according to other reports. The following experiments were carried out in order to investigate the increase of these heterophile hemagglutinins in hepatitis.
1) Sheep, goat, rabbit and chicken hemagglutinin titers were determined with serum of 274 cases of healthy persons and various diseased patients and with serum of 225 cases of hepatitis patients including infectious ones.
The relation between each hemagglutinin was examined by absorption test with each red corpuscles.
These antibodies were differentiated from the Forssman antibody, by the absorbtion test with boiled guinea pig kidney.
These experiments were carried out according to the methods reported by Davidshon, Kumagaya and Hayashi. The results were as follows.
1) H. A. in serum of hepatitis patients were often higher than in that of healthy persons or patients of other dissases. P. B. tends to increase within the normal limits. However, no relationship was observed between H. A. and P. B. Rabbit hemagglutinin fiter had also the tendency to augment in hepatitis serum.
2) Sheep and goat red corpuscles have in their antigenicity much in common.
3) Three species of red corpuscles, chicken, rabbit and goat (sheep) have only little common antigenicity with one another
4) The chicken hemagglutinin increased in hepatitis serum was not identified as normal Forssmann antibody.