1977 年 51 巻 6 号 p. 303-311
S-6436 which is a new long-acting Cefalexin preparation, has been investigated to give the following results. Pharmacokinetics of the drug were examined in 6 healthy male volunteers following 500mg single oral administration after meal. Mean peak blood level of 2.77μg/ml was obtained 6 hours after dosing. Mean 63.3% of the administered dose was excreted in the urine over 10 hours collection period.
On the clinical evaluation of the drug, 35 cases of infectious diseases, including 17 of respiratory infections, 17 of urinary tract infections and one of biliary infection, were treated with 500mg b.i.d. orally for 2 to 14 days. Two patients were cured with excellent clinical effects, 27 were good, 3 were fair and 3 were failure. As to the side effects of the drug, nausea, anorexia and diarrhea were noticed in two patients during the treatment.