A 33-year-old male was sent to our clinic for vomiting, shock, and a skin rash. Descrete pink papules became larger and purpuric within 24 hours, some of which had a central hemorrhage.
Physical and laboratory examinations revealed meningitis, herpes labialis, septic shock, DIC, adrenocortical insufficiency, and cardiac failure with evidences of myocardial infarction. N.meningitidis, serogroup B and herpes simplex virus type 1 were identified in the cultured blood and exudates of the swollen lips on the second hospital day, respectively.
The patient recovered with medications of ABPC (6-8g/day), heparin, FOY, antithrombin III, and with intensive care for cardiac-septic shock.
Hemolytic activities of the patients's compliment were less than 12/CHSO during the course. Screening for each component of the compliments and the reconstruction test of the hemolytic activity with addition of purified seventh component of compliment (C7) disclosed that this patient is a congenital deficiency of C7.
