肝臓
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
短報
Genotype1b・C型慢性肝炎に対するPeginterferon α-2b/Ribavirin/Telaprevir3剤併用療法のRapid virological responseに寄与する因子の検討:多施設共同試験
島田 紀朋厚川 正則坪田 昭人吉澤 海安部 宏加藤 慶三井家 麻紀子安達 哲史立花 浩幸佐藤 祥之戸田 剛太郎近藤 千紗福田 健坂本 長逸相澤 良夫
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2012 年 53 巻 10 号 p. 627-632

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Rapid virological response (RVR) is very important in achieving sustained virological response (SVR) to triple therapy with peginterferon alfa-2b, ribavirin and telaprevir for chronic hepatitis C. To analyze baseline factors associated with RVR, 128 Japanese patients infected with hepatitis C virus (HCV) genotype1b were subjected to this study. By univariate analysis, prior treatment response (naïve or relapse), high platelet count, low AST level, low viral load contributed significantly to RVR. By multivariate analysis, prior treatment (naïve or relapse) and low viral load were significant independent factors. Further investigation is required to clarify whether these factors may contribute to SVR and develop novel individualized treatment algorithm.

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© 2012 一般社団法人 日本肝臓学会
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