デキストラナーゼおよびα-1, 3 グルカナーゼの投与時期がハムスター実験齲蝕に及ぼす影響

抄録

The effects of commercial dextranase and Streptomyces chartreusis α-1, 3 glucanase on plaque formation and dental caries in hamsters were investigated. The hamsters grouped into two were inoculated with S. mutans AHT and received diet #2000. One group was administrated dextranase and the other α-1, 3 glucanase for the first ten days. In both groups, the extent of caries development was reduced after one month. In another experiment, one group was administrated dextranase for the first sixteen experimental days, and the other next for the same term. Both groups showed sig nificantly lower scores of dental cariesc ompared with that of the control. However difference between the two groups was not recognized. Colonization of S. mutans and plaque formation was apt to be inhibited by the dextranase.