The pioneer works of Hunt, Hoppert and co-workers on the inheritance of caries susceptibility and caries resistance in albino rats were reviewed. Though the publication of these works extended over more than twenty years, only those articles from 1948 to 1955 were able to be cited by the author owing to unavailability of their earlier works. This paper is intended to make an integral part of a review of American literatures dealing exclusively with the etiology of dental caries.