Aseismatic effects of perlite, which is used as thermal insulator in a cold box of an air separation plant, are investigated. A hysteresis loop and packing density dependence of the perlite are observed in a cyclic compressive loading test using vertical piston/cylinder apparatus. The increase in the perlite stiffness with loading cycles is also observed in a test using horizontal piston/cylinder apparatus. These phenomena are mainly explained from the fact that the perlite drops into the clearance between the piston and the compressed perlite during unloading. These deformation characteristics of perlite are modeled by a piecewise linear spring. Aseismatic effects of perlite to the air separation plant are estimated by implementing the piecewise linear spring model into a commercial finite element code.