The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
AMINO-METHYL-CYCLOHEXANE-CARBOXYLIC ACID: AMCHA
A NEW POTENT INHIBITOR OF THE FIBRINOLYSIS
SHOSUKE OKAMOTOUTAKO OKAMOTO
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JOURNAL FREE ACCESS

1962 Volume 11 Issue 3 Pages 105-115

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Abstract

1) A new potent inhibitor of the fibrinolytic system was found. Its chemical name was 1-(aminomethyl)-cyclohexane-4-carboxylic acid and abbrevi-ated as AMCHA in our laboratories.
2) The inhibitory effect of AMCHA in vitro was far more potent than that of EACA when examined by the fibrinolytic system.
3) The inhibitory effect of AMCHA given to rabbits intravenously or orally was also more potent than that of EACA when the effect was examined by the streptokinase activation test of blood samples taken at various intervals.
4) Reversal by AMCHA of the accelerated fibrinolysis in circulatory blood produced in rabbits by streptokinase was demonstrated.

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