MICROCIRCULATORY DISTURBANCES IN LOCAL ALLERGY

Abstract

The present studies described the microcirculatory disturbances during immediate type of allergic reaction on the guinea pig mesentery under the microscopic observation. The changes were obsrved for about 2 hours after topical application of the antigen. The results of these experiments were as follows.
1. The process of microcirculatory changes could be classified into two stages, the earlier and the later. In the earlier stage, stasis in capillaries and venules, erythrocytic aggregation in venules, and arteriolar contraction occurred, and recovered after several minutes duration. In the later stage, changes were mainly observed in venules; lukocytic sticking to the endothelium, leukocytic emigration, white thrombosis, and hemorrhage. Hemorrhage was observed at the points of capillary-venular or venulo-venular junctions.
2. The mechanisms of each phenomenon were discussed, and the significant role of the venule in local allergic reaction was emphasized.
The author's grateful acknowledgement is made to Prof. Dr. Kageyama for his kind guidance. Thanks are also due to Drs. Yamaguchi and Tozawa, without whose assistance and advice this project would have been impossible.