抄録
The gastric erosion was produced in guinea pigs by the injection of diphtheria toxin and the erosion became worse by the administration of hydrocortisone, and was remadkably improved by that of glucuronic acid preparation. Similar investigations were carried out on guinea pigs subjected to bilaterale enucleation of the adreals. Lesions in the gastric mucosa induced by diphtheria toxin were found to be far less severe than those of animals with the adrenals. Administration of a large dose of hydrocortisone prior to injection of the toxin enhanced the formation of gastric erosion even in the absence of the adrenals. If in this case glucuronic acid preparation was given in addition, the erosion was distinctly improved. The result seems to indicate the inhibiting effects of glucuronic acid for the activity of hydrocortisone.
