抄録
This case of cancer of the stomach was reported because of unusual multiple metastases in the spinal and cranial nerve-roots. A 48 aged woman was admitted with chief complaints of disturbance in gait, intermittent attacks of faintness and headach. During the course she had had no uspect of the stomach and bowels, and was diagnosed as having neurosyphilis on the ground of signs of progressive cerebrospinal irritations and positive serologic test for syphilis in the spinal fluid. She died about 3 months after the onset of symptoms.
Necropsy disclosed diffuse thickening of the whole stomach wall with formation of superficial ulceration and small tumor nodule. Microscopiscally the tumor tissue was made up of diffusely infiltrating cells mainly of signet-ring-cell structure (Carcinoma simplex mucocellulare). By the way of lymphatic and transcoelomic dissemination metastases were formed in the retroperitoneal lymphnodules and pelvic organs. Tumor cells made also a prominent invasion upon the spinal and cranial nerve-roots, as well as upon the leptomeninges. Examinations of the peripheral nerves disclosed diffusely infiltrating tumor cells along the nerve sheaths. Their proximal growth, however, were found restained by the terminal zone of the spinal horn.
It seems reasonable to conclude that malignant tumor cells may reach the spinal cavity through the rout along the perineural lymphspaces rather than by the blood-stream.
