臓器動脈硬化の形態学的差異, とくに脳, 冠状, 腎動脈硬化の形態学的特徴について
1976 年 26 巻 6 号 p. 469-487
詳細
1976 年 26 巻 6 号 p. 469-487
In order to clarify morphological differences of arteriosclerosis in various visceral arteries, the cerebral, coronary and renal arteries were morphometrically and histologically investigated.
1. Hypertension enhanced the grade of arteriosclerosis of the major cerebral arteries as well as that of the intracerebral small arteries. The enhancement was markedly observed in cases over age 40.
2. Morphological findings of intracerebral arteriosclerosis were more varied than those in other organs. They were cellulofibrous intimal thickening, atherosclerosis, intimal lipoidosis, intimal edema and fibro-nodular arterial lesions, and others in hypertensive brains.
3. The grade of coronary sclerosis was also increased by hypertension. The effect of hypertension on the coronary arteries was more slight than that on the cerebral arteries.
4. Newly formed capillaries in the thickened intima were found more frequently in the coronary arteries than the other arteries. They might play a role in exacerbation of atherosclerosis.
5. Morphological pictures of intramyocardial coronary sclerosis were cellulofibrous intimal thickening and mucoid degeneration. For the pathogenesis of the latter not only hypertension but also hypoxia was considered responsible.
6. Histological characteristics of intrarenal arteriosclerosis were intimal laminated elastosis and arteriolar hyalinosis. The severity of the former was increased with hypertension and aging. It was suggested that the elastic fibers in the elastosis were produced by intimal smooth muscle cells. Hyaliosis of arterioles in the kidney had a close relation to hypertension. There was a positive parallelism between the grade of the hyalinosis and cerebral arteriosclerosis.
7. It could be concluded that the differences in histological features and development-grade of arteriosclerosis among various visceral organs were induced by the differences of arterial wall architecture and of hemodynamics, both of them depending on the characteristic organ functions.
