ショックの病態とライソゾーム (1) ショック患者における血漿ライソゾーム酵素の動態

抄録

Plasma lysosomal enzyme activities were determined in 55 shocked patients and 36 patients received open heart surgery under extracorporeal circulation. Plasma β-glucuronidase in shocked patients depicted a higher value than control one in unshocked patients. Mortality rate of the patients increased parallel to the elevation of plasma concentration of the lysosomal hydrolase. However, 47 percent of shocked patients failed to show a release of the enzyme into the circulating blood. It was observed that β-glucuronidase and cathepsin-D in plasma elevated significantly after 60 minutes of extracorporeal perfusion. These results suggest that lysosomal hydrolases release into circulation from ischemic region during shock and hypoperfusion state.