ショックの病態とライソゾーム (2) ライソゾーム酵素の起源

抄録

The present study was undertaken to determine the contribution of pancreas as a source of plasma lysosomal enzymes released during shock. In part one, mongrel dogs were subjected to splanchnic ischemia shock by the temporary ligation of superior mesenteric and celiac arteries. Plasma levels of β-glucuronidase had been raised during ischemia and reached a 4.4 times of sham operated control values in the terminal stage after release of ligation. Pancreatectomy being performed just prior to arterial occlusion failed to yield those significant rise of plasma β-glucuronidase. Diversion of thoracic duct lymph during ischemia also suppressed the increase of plasma lysosomal enzyme. In part two, Dogs which had received chronic ligation of pancreatic ducts for the atrophy of exocrine glandular cells were led to hemorrhagic shock according to the Wiggers' technic. There were significant differences in plasma lysosomal hydrolase levels between ductligated and control groups after 120 minutes of oligemic hypotension.
Those findings lead to a conclusion that lysosomal enzymes released into circulating blood during shock originate primarily from ischemic pancreas.