正常若年者及び本態性高血圧者における起立負荷, 数唱負荷試験-特に高血圧遺伝素因と交感神経副腎系活動性を中心として-

抄録

Blood pressure, pulse rate, plasma catecholamine and plasma renin activity in response to standing and mental stress were studied in 28 normotensive subjects, 14 borderline hypertensive patients (BHT group) and 14 patients with essential hypertension (EHT group). The normotensive subjects were further divided into 2 groups : 14 subjects with normotensive parents (PNT group) and 14 with hypertensive parent (s) (PHT group).
Mean basal norepinephrine of the BHT and EHT groups was significantly higher than that of the PNT group. The increases in blood pressure, pulse rate and plasma norepinephrine in response to standing and mental stress were lower in the EHT group than in the other three groups. The increase in plasma epinephrine in response to mental stress was higher in the PHT and BHT groups than in the PNT and EHT groups.
A higher incidence of high blood pressure in response [≥ 20mmHg in systolic blood pressure] (higher responders) to mental stress was found in the PHT, BHT and EHT groups compared with the PNT group. The increases in plasma epinephrine of the higher responders to mental stress in all groups were higher than in the lower responders [≤19mmHg in systolic blood pressure to mental stress], and basal plasma epinephrine in the higher responders was higher than in the lower responders.
The results indicate that the genetic predisposition to hypertension plays a significant role in determining plasma catecholamine levels and the responsiveness to stress, especially to mental stress.