2010 Volume 67 Issue 9 Pages 549-552
Alginate micro-gel (AMG) containing a model compound, hydrocortisone (HC), was prepared by high pressure water method. The release profile of HC from AMG was then investigated. The mean particle size of AMG was less than 100 μm: the size was controllable by the pressure of water. HC incorporated in AMG was immediately dissolved in physiological saline; the dissolution profile was reproducible. These results suggest that AMG is potentially useful to improve the solubility of water-insoluble compounds.