2016 Volume 73 Issue 1 Pages 1-11
The conjugation of organometallic complexes with dipeptides or nucleobases was used to design bioorganometallic compounds. The introduction of the chiral dipeptide chains into ferrocene as a reliable organometallic scaffold induces the conformational enantiomerization of the ferrocenyl moiety based on the chirality-organized structure, via intramolecular hydrogen bonding. The configuration and sequence of amino acids play an important role in the construction of the chirality-organized bio-inspired systems with controlled hydrogen bonds. The conjugation of organometallic complexes with nucleobases was also demonstrated to afford bioorganometallic conjugates. An interesting feature of bioorganometallic conjugates is their strong tendency to self-assemble through intermolecular hydrogen bonds between their uracil moieties, wherein hydrogen bonding patterns were found to depend on the direction of hydrogen bonding sites.
