The Catalytic Activity of the Optically Active N-Acylated Polyethylenimines on the Hydrolysis of Optically Active

Abstract

N-Acylated poly- (R) -2-ethylethylenimines (API) were synthesized by the reaction of various acyl chlorides with poly- (R) -2-ethylethylenimine (PEEI) and their catalytic effect of the hydrolysis of p-nitrophenyl acetate, benzyloxycarbonyl- (D or L) -valine p-nitrophenyl ester (Z- (D or L) -ValONp) and benzyloxycarbonyl- (D or L) -phenylalanine p-nitrophenyl ester (Z- (D or L) -PheONp) was determined. The hydrolysis of p-nitrophenyl ester derivatives by API followed the Michaelis-Menten mechanism, and the rates were larger than the value for PEEL The selective hydrolyses of the enantiomeric substrates Z-ValONp and Z-PheONp catalyzed by API were faster for L-isomer than D-isomer.