Abstract
In order to evaluate the biocompatibility of polymers which were surface-modified with both glucose and phosphorylcholine moieties, a series of polymer microspheres P (MPC/GEMA-co-MMA) was prepared by soap-free emulsion copolymerization of methyl methacrylate (MMA) with 2-methacryloyloxy ethylphosphorylcholine (MPC) and 2- (glucosyloxy) ethyl methacrylate (GEMA). From XPS measurements, MPC and GEMA moieties are concentrated on the surfaces of the particles. It was also found that P (MPC/GEMA-co-MMA) forms a hydrogel structure on the surface of the particles and suppresses the adsorption of both bovine serum albumin and human serum γ-globulin, but less than PMMA microspheres. In a cell culture test, films prepared from the polymer microspheres showed normal adhesiveness of mouse fibroblast (L-929). These findings indicate that the modification of the surfaces of polymer materials with both MPC and GEMA moieties is useful for improving biocompatibility.
