Recently there were typical reports about the serious side-effect syndromes for the medicated cosmetics in Japan. One side-effect symptom was due to medicated soap with the hydrolyzed wheat powder so-called as “Cha No Sizuku Sekken.” This symptom was called as the food-dependent exercise-induced anaphylaxis (FDEIA). Another side-effect symptom was caused to rododendrol (4-(4-hydroxyphenyl)-2-bunanol, HPBol) as the whitening agent. HPBol happened the serious side-effect of vitiligo against many users. In this report, I explain to describe the position of quasi drugs in Japan and to make clear to both the distribution of molecular weight about the hydrolyzed wheat powder described by Dr. Yoshiaki Ikarashi and the cause of giving the side-effect of rododendrol described by Takumi Akiyama.