光線力学療法に用いる光増感剤の開発：ケイ素置換基の利用

抄録

Photodynamic therapy has been accepted as a promising treatment for cancer, and improvements of photosensitizers of reactive oxygen species are important to develop photodynamic therapy. We have developed silyl-substituted porphyrin derivatives to improve the activity of photosensitizer. We found that silylation of porphyrins improved the quantum yield of singlet oxygen sensitization, cellular uptake efficiency, and accumulation efficiency to tumor tissue. Based on these improvements, silylation enhanced the in vivo photodynamic activity. We have also tried to develop the activatable photosensitizers to suppress the photo-induced side effect. We demonstrated that the aggregate of the silylated porphyrin derivative can be applicable to a sono-activatable photosensitizer.